The invention provides glycopEGylated G-CSF, which has therapeutic activity and has pharmacokinetic parameters and properties that are improved compared to an identical or closely analogous peptide G-CSF, which is not glycopEGylated. Further, the invention provides methods for stimulating hematopoiesis in a subject, especially in a subject that has undergone or will undergo radiation or chemical therapy. The methods and compositions of the invention can further be used to prevent, alleviate and treat the myelosuppressive effects of such therapies. The application for this invention claims priority according to the filing date of provisional application for US patent No. Granulocyte colony stimulating factor O-C8P is a glycoprotein that stimulates the survival, proliferation, differentiation and function of progenitor cells of neutrophilic granulocytes and mature neutrophils. Both forms of recombinant human O-S8G used in the clinic are powerful neutrophil granulopoiesis stimulants effective in preventing the infectious complications of certain neutropenic conditions.
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We will begin by looking at some prerequisites that need to be satisfied before getting started with the actual AWS SSL certificate installation process. It includes unlimited server licenses, reissuances, bit encryption, and more. This process can be done either by using an online conversion tool or by using the OpenSSL library. Note: The OpenSSL library can also be used to convert certificate files from other formats such as pkcs 7, pfx, etc. For those of you comfortable using the command line interface CLI , run the command below, modifying it as required, with your certificate files. Alternatively, you can follow the instructions in the next section to upload your certificates if you want to avoid using the command line interface.
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